Abstract #1886
Development of Hyperpolarized 13C-MRS Probes for Oxidative Stress measurement
Arif Wibowo 1 , Jae Mo Park 2 , Ralph Hurd 3 , Graham F Sommer 4 , Chaitan Khosla 5 , and Daniel M Spielman 6
1
arifw@stanford.edu, Stanford, CA, United
States,
2
Stanford,
CA, United States,
3
GE
healthcare, CA, United States,
4
Diagnostic
Radiology, Stanford University, CA, United States,
5
Chemistry
and ChEM-H, Stanford University, CA, United States,
6
Radiology,
Stanford University, CA, United States
In this study, we evaluated the potential of cysteine
(Cys), N-acetyl cysteine (NAC), and Mercaptopyruvate
(MCP as hyperpolarized 13C substrate for assessing
oxidative stress (OS) in vivo. Of these, MCP was
identified as a viable substrate for in vitro OS
assessment, and we are currently developing large-scale
MCP synthesis for testing the potential of this
substrate for in vivo OS measurements.
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