Abstract #1770
CEST and FLEX MRI for detection of CNS graft rejection
Sujith V Sajja 1,2 , Guanshu Liu 1,3 , Nirbhay Yadav 1,3 , Jiadi Xu 3 , Antje Arnold 1,2 , Anna Jablonska 1,2 , Michael McMahon 1,3 , Peter van Zijl 1,3 , Jeff Bulte 1,2 , Piotr Walczak 1,4 , and Miroslaw Janowski 1,5
1
Dept. of Radiology and Radiological Science,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States,
2
Cellular
Imaging Section and Vascular Biology Program, Institute
for Cell Engineering, Johns Hopkins University,
Baltimore, MD, United States,
3
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, MD, United States,
4
Department
of Radiology, University of Warmia and Mazury, Olsztyn,
Poland,
5
NeuroRepair
Department, Polish Academy of Sciences, Warsaw, Poland
Conventional imaging such T1, T2 has been widely used to
study gross anatomical changes and edema in brain. Stem
cell transplantation has become attractive for
regenerative medicine, but, grafts take months to years
to become fully functional and could be rejected during
this process. Non-invasive modalities to study CNS graft
rejection clinically are currently unavailable. Progress
in MR is providing access to molecular level changes
including graft rejection process. Here we show that
CEST and FLEX MRI may aid in detection of the process of
rejection that could be tailored to individual grafts
within the paradigm of personalized medicine.
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