Abstract #1769
Breath-hold CEST-MRI of Liver Cirrhosis: A Clinical Feasibility Study
Xin Chen 1 , Weibo Chen 2,3 , Guangbin Wang 1 , Jianhua Lu 4 , Jinyuan Zhou 5 , Guang Jia 4,6 , and Jianqi Li 3
1
Shangdong Medical Imaging Research
Institute, Shangdong University, Jinan, Shandong, China,
2
Philips
Healthcare, Shanghai, China,
3
Shanghai
Key Laboratory of Magnetic Resonance and Department of
Physics, East China Normal University, Shanghai, China,
4
Department
of Physics and Astronomy, Louisiana State University,
Baton Rouge, LA, United States,
5
Johns
Hopkins University, Baltimore, MD, United States,
6
Pennington
Biomedical Research Center, Baton Rouge, LA, United
States
Liver cirrhosis is one type of glycogen storage disease
without an increased amount of glycogen. Instead, the
glycogen that does build up in the liver has very long
outer branches, which may have a significant
contribution to the transfer ratio of hydroxyl protons
in CEST-MRI measurements. We have shown that it is
clinically feasible to obtain CEST spectra in the liver
with the breath-hold technique. Liver cirrhosis
exhibited a significantly higher MTR at the resonance
frequency of hydroxyl protons (1.2ppm), indicating a
higher concentration of glycogen outer branches in liver
cirrhosis.
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