Abstract #1723
A Dixon Method for Positive Contrast Imaging of Very Small Superparamagnetic Iron Oxide Nanoparticles in MRI
Dirk Krger 1 , Silvia Lorrio Gonzlez 1 , and Ren M. Botnar 1
1
Division of Imaging Sciences & Biomedical
Engineering, King's College London, London, United
Kingdom
The aim of this project is to develop and validate a
Dixon MR imaging technique to achieve positive contrast
of very small superparamagnetic iron oxide nanoparticles
(VSOPs). We assessed the proposed method in a phantom
study and compared the results with three established
positive contrast imaging techniques. The reference
techniques were GRadient-echo Acquisition for
Superparamagnetic particles (GRASP), Inversion Recovery
with ON-resonant water suppression (IRON), and
Susceptibility Gradient Mapping (SGM). The Dixon method
demonstrated superior sensitivity, relative ease of
implementation and reliability.
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