Abstract #1722
Quantification of Labeled Cell Clusters in a Rat Brain In Vivo Using MRI
Paul Kokeny 1 , Xie He 2 , Saifeng Liu 3 , Ching-Yi Hsieh 4 , Quan Jiang 5,6 , Yu-Chung Norman Cheng 1 , and E. Mark Haacke 1,4
1
School of Biomedical Engineering, Wayne
State University, Detroit, MI, United States,
2
School
of Physics, Wayne State University, Detroit, MI, United
States,
3
School
of Biomedical Engineering, McMaster Univeristy,
Hamilton, Ontario, Canada,
4
Department
of Radiology, Wayne State University, Detroit, MI,
United States,
5
Department
of Neurology, Henry Ford Health System, Detroit, MI,
United States,
6
Department
of Radiology, Henry Ford Health System, Detroit, MI,
United States
Currently, the tracking of nanoparticle labeled cells
via MRI is a qualitative process. However, given the
magnetic moment of a labeled cell cluster along with the
mass magnetization of the labeling agent and the average
cellular iron uptake, it is possible to estimate the
number of cells present in a cluster in vivo. In this
work, the magnetic moments of six labeled cell clusters
are quantified using a complex summation method that is
accurate for small objects. The effect of high-pass
filtering is analyzed through simulations. From these
results, the number of cells present in each cluster is
estimated.
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