Abstract #1634
MRI-Guided Transurethral Ultrasound Therapy of the Prostate Gland using Real-Time Thermal Mapping: An Analysis of Technical Accuracy and Immediate Postinterventional Assessment of Tissue Destruction via CE-MRI
Maya Barbara Mller-Wolf 1 , Mathieu Burtnyk 2 , Valentin Ionel Popeneciu 3 , Gencay Hatiboglu 3 , Michele Billia 4 , Cesare Romagnoli 5 , Joseph Chin 4 , Sascha Pahernik 3 , Heinz-Peter Schlemmer 6 , and Matthias C Roethke 1
1
Radiology, German Cancer Research Center,
Heidelberg, Baden-Wuerttemberg, Germany,
2
Profound
Medical, Toronto, Ontario, Canada,
3
Urology,
University Hospital Heidelberg, Heidelberg,
Baden-Wuerttemberg, Germany,
4
Urology,
Western University UWO London Victoria Hospital, London,
Ontario, Canada,
5
Radiology,
Western University UWO London Victoria Hospital, London,
Ontario, Canada,
6
Radiology,
German Cancer Research Center, Baden-Wuerttemberg,
Germany
Local disease control and low morbidity are goals of
minimally-invasive, image-guided therapies for localised
prostate cancer. MRI-guided transurethral ultrasound
ablation constitutes an attractive treatment alternative
to active surveillance and radical treatments. Real-time
MR-thermometry and active temperature feedback control
enable assessment of treatment success through thermal
dosimetry and visualization of immediate
post-interventional contrast-enhanced MRI. A prospective
phase I trial was conducted to determine targeting
accuracy of conformal heating to predefined acute
ablation boundary (T2-planning) using linear and
volumetric metrics including Dice Similarity
Coefficient. Thermal coagulation was confirmed by
visually comparing the MR-thermometry images to the
non-perfused volume on CE-MRI.
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