Abstract #1564
Multiparametric MRI Evaluation of Chronic Kidney Disease BOLD & Diffusion MRI
Lu-Ping Li 1 , Wei Li 1 , Jon Thacker 1 , Huan Tan 1 , Ying Zhou 2 , Orly Kohn 3 , Stuart Sprague 4 , and Pottumarthi V. Prasad 1
1
Center for Advanced Imaging, NorthShore
University HealthSystem, Evanston, IL, United States,
2
Center
for Biomedical Research & Informatics, NorthShore
University HealthSystem, Evanston, IL, United States,
3
Department
of Nephrology, University of Chicago, Chicago, IL,
United States,
4
Department
of Nephrology, NorthShore University HealthSystem,
Evanston, IL, United States
With the increasing prevalence of chronic kidney disease
(CKD), the cost of care is a tremendous economic burden
to healthcare system. With the lack of markers specific
to CKD and to evaluate risk of progression, management
is uniform and sub-optimal. The progression of CKD is
thought to involve renal hypoxia and fibrosis. Blood
oxygenation level dependent (BOLD) and diffusion MRI
allow for non-invasive evaluation of renal hypoxia and
fibrosis respectively. Here we show preliminary data
with R2* and ADC in a group of CKD patients with
diabetes compared to healthy controls. CKD had higher
R2* and lower ADC values.
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