Abstract #1562
Multi-parametric MRI Evaluation of Chronic Kidney Disease BOLD & Perfusion MRI
Jon Thacker 1 , Huan Tan 2 , Lu-Ping Li 2,3 , Wei Li 2,3 , Ying Zhou 3 , Orly Kohn 2 , Stuart Sprague 2,3 , and Pottumarthi Prasad 2,3
1
Northwestern University, Chicago, Illinois,
United States,
2
University
of Chicago, Illinois, United States,
3
NorthShore
University HealthSystem, Illinois, United States
A joint BOLD and ASL MRI assessment of renal oxygenation
and perfusion was performed in subjects with stage-3 CKD
with diabetes. This group was found to have lower renal
oxygenation levels (increased R2*) and decreased
perfusion compared to a group of controls. A significant
correlation was observed between perfusion and eGFR, and
a negative correlation between R2* and eGFR. There was
significant negative correlation between R2* and
perfusion. These observations are consistent with
chronic hypoxia theory.
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