Abstract #1492
Mapping 129 Xenon ADC of Radiation-Induced Lung Injury at Low Magnetic Field Strength Using a Sectoral Approach
Krzysztof Wawrzyn 1,2 , Alexei Ouriadov 1 , Elaine Hegarty 1 , Susannah Hickling 3 , and Giles Santyr 1,4
1
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
2
Department
of Medical Biophysics, Western University, London,
Ontario, Canada,
3
Department
of Medical Physics, McGill University, Montreal, Quebec,
Canada,
4
The
Peter Gilgan Centre for Research and Learning, The
Hospital for Sick Children, Toronto, Ontario, Canada
Early diagnosis of radiation-induced lung injury
following radiotherapy is critical for prevention of
permanent lung damage. MRI of the apparent diffusion
coefficient (ADC) of hyperpolarized xenon-129 gas shows
promise for early measurement of RILI. A UTE sequence
based on a pseudo non-Cartesian k-space trajectory (i.e.
Sectoral) is implemented at low field (0.07 T) for
efficient use of the non-renewable magnetization of
xenon-129. A pilot study demonstrated Sectoral ADC
mapping on healthy and 2-weeks post irradiated rats. A
significant correlation between ADC and mean linear
intercept from histology was observed and a separation
between the cohorts was observed with FWHM ADC.
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