Abstract #1491
129 Xe Dynamic Spectroscopy and Modelling: A Repeatability and Method Comparison Study
Neil James Stewart 1 , Helen Marshall 1 , and Jim Michael Wild 1
1
Academic Unit of Radiology, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom
The intra-subject variability (repeatability) of
quantitative parameters derived from the
129
Xe
chemical shift saturation recovery (CSSR) and
red-blood-cell-to-tissue signal ratio (RBC-T/P) methods
was evaluated to assess their sensitivity in identifying
early-stage interstitial lung disease (ILD). Five
healthy volunteers were scanned on three separate
occasions using two implementations of the
129
Xe
CSSR sequence existing in literature. Intra-subject
standard deviations and repeatability coefficients of
CSSR-derived septal thickness and RBC-T/P ratio values
were considerably less than previously-measured
differences between normals and ILD patients. However,
derived surface-area-to-volume ratio and capillary
transit time parameters were substantially variable and
cannot be considered as robust quantitative markers.
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