Abstract #1366
Real-time fMRI Neurofeedback with Simultaneous EEG in Combat-related PTSD: Identification of EEG Measures of PTSD Severity and Treatment Response
Vadim Zotev 1 , Raquel Phillips 1 , Masaya Misaki 1 , Chung Ki Wong 1 , Brent Wurfel 1 , Matthew Meyer 1,2 , Frank Krueger 1,3 , Matthew Feldner 1,4 , and Jerzy Bodurka 1,5
1
Laureate Institute for Brain Research,
Tulsa, OK, United States,
2
Laureate
Psychiatric Clinic and Hospital, Tulsa, OK, United
States,
3
Neuroscience
Dept., George Mason University, Fairfax, VA, United
States,
4
Dept.
of Psychological Science, University of Arkansas,
Fayetteville, AR, United States,
5
College
of Engineering, University of Oklahoma, Tulsa, OK,
United States
We have performed emotion regulation training in
veterans with combat-related PTSD using real-time fMRI
neurofeedback (rtfMRI-nf) with simultaneous EEG. Six
PTSD patients learned to upregulate their left amygdala
activity using rtfMRI-nf during a positive emotion
induction task based on retrieval of happy
autobiographical memories. We observed task-dependent
variations in frontal EEG asymmetry (FEA) in the upper
alpha band that correlated with PTSD severity (CAPS).
Individual changes in CAPS ratings significantly
correlated with changes in FEA variations. The results
suggest that variations in FEA during rtfMRI-nf training
may provide a sensitive measure of PTSD severity and
individual response to treatment.
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