Abstract #1345
Physiological characterization of a robust survival rodent fMRI method
Hanbing Lu 1 , Julia K Brynildsen 1 , Li-Ming Hsu 1 , Thomas Ross 1 , Elliot A Stein 1 , and Yihong Yang 1
1
Neuroimaging Research Branch, National
Institute on Drug Abuse, NIH, Baltimore, MD, United
States
Proper choice of anesthetics is of critical importance
for the success of an fMRI experiment. An anesthetic
regime that uses low dose of dexmedetomidine in
combination with low dose of isoflurane, permitted fMRI
data acquisition for several hours. The rat default mode
brain network has been successfully identified with this
preparation, indicating that this protocol minimally
disturbs brain network functions. However, medetomidine
is known to cause peripheral vasoconstriction,
respiratory suppression and bradycardia, confounding the
fMRI signal. The goal of this study is to systematically
characterize and to optimize physiological conditions
for fMRI experiment under this anesthetic regimen.
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