Abstract #1331
Age-related increased R2 and R2* correlates with increased brain iron in a normal ageing mouse model
Thomas Walker 1 , Christos Michaelides 1 , Harry Parkes 2 , William Crum 1 , Tina Geraki 3 , Amy Herlihy 4 , and Po-Wah So 1
1
Department of Neuroimaging, Institute Of
Psychiatry, King's College London, London, United
Kingdom,
2
CR-UK,
Clinical MR Research Group, Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
3
Diamond
Light Source, Harwell Science and Innovation Campus,
Didcot, Oxfordshire, United Kingdom,
4
Agilent
Technologies, Yarnton, Oxfordshire, United Kingdom
Brain iron accumulation with ageing may play a role in
senescent processes, with age-related increases in basal
ganglia R2 and R2* observed in man and associated with
increased iron. Here, we show similar increases in R2
and R2* in the basal ganglia of ageing C57BL/6J mice.
Quantitatively measured increased iron by synchrotron
radiation X-ray fluorescence elemental iron mapping
suggests the increased R2 and R2* values may indeed
arise from higher iron concentrations. Thus, iron
dyshomeostasis may play a role in ageing and MR
relaxometry may be used to monitor these ageing
processes.
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