Brain Expansion Capacity: measuring brain volume adaptation to water loading in the human brain

Based on age-related differences in the response of animals to experimentally-induced water intoxication, we hypothesize that the degree of tissue swelling is an intrinsic, age-dependent property of brain tissue that we have named the expansion capacity, . The expansion capacity is a measure of the capability of tissue to accomodate osmotically induced volume increases in the CNS. This includes the effects of the osmotic regulatory systems (both local and systemic) and the biomechanical properties of the tissue. Here we introduce the basic concept of the expansion capacity and attempts to measure it in a group of healthy adults.

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