Abstract #1322
Neural and cognitive substrates of omega-3 fatty acid supplementation: a voxel-based morphometry study in aged mice
Marco Pagani 1,2 , Debora Cutuli 3,4 , Adam Liska 1 , Paola Caporali 3,4 , Daniela Laricchiuta 3,4 , Francesca Foti 3,4 , Cristina Neri 4 , Laura Petrosini 4 , and Alessandro Gozzi 1
1
CNCS, Istituto Italiano di Tecnologia - IIT,
Rovereto, TN, Italy,
2
CIMeC
- Center for Mind and Brain Sciences, UNITN - Universit
di Trento, Rovereto, TN, Italy,
3
University
Sapienza, Rome, Rome, Italy,
4
Santa
Lucia Foundation, Rome, Rome, Italy
Human studies have revealed a neuroprotective effect of
omega-3 polyunsaturated acids (n-3 PUFA) in aging, with
a positive correlation between peripheral n-3 PUFA
levels and hippocampal volume. Consistently, higher
dietary n-3 PUFA levels have been associated with
delayed/reduced cognitive decline. To demonstrate a
causal relationship between n-3 PUFA intake, cognition
and brain morphology, we mapped gray-matter volume and
recorded cognitive performance in aged mice upon
8-week-treatment with n-3 PUFA or control fatty acid. We
show that n-3 PUFA treated-mice exhibit better cognitive
performance and greater hippocampal and prefrontal
volume, an effect that was strongly correlated with
brain n-3 PUFA concentration.
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