Abstract #1293
Altered functional and structural connectivities within defalut mode network in adolescents with autism spectrum disorder
Hsiang-Yun Sherry Chien 1 , Susan Shur-Fen Gau 2 , Yu-Jen Chen 1 , Yu-Chun Lo 1 , Hsiang-Yuan Lin 2 , Yung-Chin Hsu 1 , and Wen-Yih Isaac Tseng 1,3
1
Center for Optoelectronic Medicine, National
Taiwan University College of Medicine, Taipei, Taiwan,
Taiwan,
2
Department
of Psychiatry, National Taiwan University College of
Medicine, Taipei, Taiwan, Taiwan,
3
Molecular
Imaging Center, National Taiwan University, Taipei,
Taiwan, Taiwan
In the present study, we investigated the functional
connectivity (FC) and structural connectivity (SC)
within default mode network (DMN) simultaneously in
normal adolescents and adolescents with autism spectrum
disorder (ASD). We found that all the indices tended to
be lower in adolescents with ASD compared to TD,
especially in the SC of the right cingulum. Furthermore,
the FC-SC correlation patterns showed opposite
directions on both sides and were significantly
different on the right side between the two groups. This
might imply the abnormal DMN development in individuals
with ASD during their adolescence.
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