Abstract #1292
Multi-parametric Magnetic Resonance to Investigate Aggression: A Study at 11.7T on the BALB/cJ Mouse Model
Houshang Amiri 1,2 , Amanda Jager 2 , Sjaak J. A. van Asten 1 , Arend Heerschap 1 , and Jeffrey Glennon 2
1
Department of Radiology, Radboud University
Medical Center, Nijmegen, Gelderland, Netherlands,
2
Department
of Cognitive Neuroscience, Radboud University Medical
Center, Nijmegen, Gelderland, Netherlands
Aggressive behaviour is a key symptom of conduct
disorder (CD). Therefore, animal models of aggression
could provide more knowledge about the neural substrates
underlying CD and could provide new insights in possible
treatments to treat or prevent this disorder. We first
extensively phenotyped the BALB/cJ mice (as an
aggressive model) in terms of aggression, anxiety,
impulsivity, compulsivity and attention. Then, a
multiparametric MR experiment including DTI, ASL, and
MRS was performed. Our findings suggest that
pathological aggression observed in the BALB/cJ mice is
likely related to structural and neurochemical changes
leading to inattention and anxiety.
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