Abstract #1279
Metabolite distributions in human aging brain - a study with short-TE whole brain MR spectroscopic imaging
Xiao-Qi Ding 1 , Helen Maghsudi 1 , Andrew A. Maudsley 2 , Mohammad Sabati 2 , Sulaiman Sheriff 2 , Martin Schtze 1 , Paul Bronzlik 1 , and Heinrich Lanfermann 1
1
Institute of Diagnostic and Interventional
Neuroradiology, Hannover Medical School, Hannover, Lower
Saxony, Germany,
2
Department
of Radiology, University of Miami School of Medicine,
Miami, FL, United States
Metabolite concentrations in multiple brain structures
of 60 healthy adults (21 - 70 years) were measured by
using a short TE (17.6 ms) whole brain MR spectroscopic
imaging (wbMRSI). The distributions as well as the
age-related changes of brain metabolites NAA, tCho, tCr,
mI, and Glx were regional and metabolite dependent. The
most age-related changes were observed in metabolite NAA
with age-related decreases in seven of thirteen selected
brain structures and the cerebrum revealed more local
metabolic changes than that in cerebellum.
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