Abstract #1256
Kinetic oscillatory stimulation (KOS) in the nasal cavity studied by resting-state fMRI
Tie-Qiang Li 1 , Rolf Hallin 2 , and Jan-Erik Juto 3
1
Department of Medical Physics, Karolinska
University Hospital, Karolinska Huddinge, Stockholm,
Sweden,
2
Department
of Neurophysiology, Karolinska University Hospital,
Karolinska Huddinge, stockholm, Sweden,
3
Department
of CLINTEC, Karolinska Institute, Huddinge, stockholm,
Sweden
Kinetic oscillatory stimulation (KOS) in the nasal
cavity has been shown to be effective for treating acute
migraine and inflammation. We aimed to better understand
the neurological mechanisms underlying KOS treatment. We
used a resting-state fMRI protocol that fits the
treatment inside MRI scanners and a metric based on the
number of significant functional connections to quantify
BOLD response to KOS treatment. Our results demonstrate
that migraine is associated with enhanced functional
modulations within the control network of the autonomous
nervous system and KOS treatment results in
significantly different responses between normal
controls and migraine patients.
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