Abstract #1255
4D Phase Contrast EPI for assessing 3D volumetric strain rate in the human brain over the cardiac cycle
Nils Noorman 1 , Sebastian Hirsch 2 , Jrgen Braun 3 , Peter R. Luijten 1 , Ingolf Sack 2 , and Jaco J.M. Zwanenburg 1
1
Department of Radiology, University Medical
Center, Utrecht, Utrecht, Netherlands,
2
Department
of Radiology, Charit - Universittsmedizin Berlin,
Berlin, Germany,
3
Institute of Medical
Informatics, Charit - Universittsmedizin Berlin,
Berlin, Germany
The pulsating heart induces volumetric strain pulsations
in the brain, which drive the interstitial transport of
metabolites and waste products. This feasibility study
mapped these volumetric strain rates for the first time
with a time resolved 3-dimensional phase contrast (3D
PCA) sequence (0.3 cm/s encoding velocity), over the
entire brain and cardiac cycle (74 ms temporal
resolution). The shapes of the strain rate curves
obtained in four volunteers were similar to previous
studies using different techniques. However, the
magnitude was approximately 5 times larger, requiring
further validation before using this technique as a tool
for studying brain (patho)physiology.
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