Abstract #1230
Quantification of the inflammatory process in muscles of patients with facioscapulohumeral muscular dystrophy.
Linda Heskamp 1 , Barbara H. Janssen 1 , and Arend Heerschap 1
1
Radiology, Radboud university medical
center, Nijmegen, Netherlands
The aim of this study was to develop a method to
quantify measures of severity of inflammation as seen on
TIRM images in patients with fascioscapulohumeral
muscular dystrophy (FSHD). Intensity (in standardized
z-scores) and volume of inflammation were quantified on
TIRM images in six muscles of three patients at baseline
and follow-up. We observed that three processes occurred
over time. The volume and intensity of inflammation both
1) increased, 2) decreased, 3) volume decreased, while
intensity increased. Thus, the proposed method is able
to quantify features of the inflammatory process in FSHD
patients, which may be valuable to evaluate treatment.
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