Abstract #1229
Inter-echo time dependence of CPMG relaxation rate around capillaries in skeletal muscle tissue
Felix T Kurz 1 , Thomas Kampf 2 , Lukas R Buschle 3 , Sabine Heiland 4 , Martin Bendszus 4 , and Christian H Ziener 1,3
1
Heidelberg University, Heidelberg, BW,
Germany,
2
University
of Wuerzburg, Bavaria, Germany,
3
German
Cancer Research Center, Heidelberg, BW, Germany,
4
Heidelberg
University, BW, Germany
Capillary networks in muscle tissue are examined using
Kroghs capillary model and it is shown that
diffusion-dependent CPMG relaxation rates depend on
microstructural parameters such as capillary radius,
nuclear spin diffusion and regional blood volume
fraction. The findings agree well with experimental data
and can be used to quantify microstructural parameters
that correlate with denervation- or age-related
microcirculatory remodeling in skeletal muscle.
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