Abstract #1226
Muscular fat fraction determination by quantitative T2-MRI, reproducibility in facioscapulohumeral muscular dystrophy and healthy volunteers
Linda Heskamp 1 , Barbara Helena Janssen 1 , and Arend Heerschap 1
1
Radiology, Radboud university medical
center, Nijmegen, Netherlands
The aim of this study was to assess the reproducibility
of quantitative T2-MRI determined muscular fat fraction
in patients with fascioscapulohumeral muscular dystrophy
(FSHD) and healthy volunteers. Fat content was derived
from multi spin-echo images of 80 FSHD muscles and 45
healthy volunteer muscles by fitting the
signal-intensity to a bi-exponential function with fixed
T2 times for muscle and fat. Reproducibility was
assessed by a Bland-Altman analysis. The coefficient of
repeatability for FSHD muscles and healthy muscles were
6.5% (1.96*SD) and 2.8% (1.96*SD), respectively. With
this reproducibility, treatment effects of 2.5% can be
detected in a patient cohort < 10.
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