Abstract #1225
Dynamic measurement of muscle R2, R2' and R2* during ischemia and reactive hyperemia
Chengyan Wang 1 , Rui Zhang 2 , Xiaodong Zhang 3 , He Wang 4 , Kai Zhao 3 , Jue Zhang 1,2 , Xiaoying Wang 1,3 , and Jing Fang 1,2
1
Academy for Advanced Interdisciplinary
Studies, Peking University, Beijing, Beijing, China,
2
College
of Engineering, Peking University, Beijing, China,
3
Department
of Radiology, Peking University First Hospital, Beijing,
China,
4
Philips
Research China, Shanghai, Shanghai, China
Muscle BOLD MRI has been used to infer small vessel
function following arterial occlusion, the infusion of
vasoactive compounds and to study vascular function in
peripheral artery disease. BOLD R2* is a summation of
irreversible (R2) and reversible(R2) relaxation rates
(R2*=R2+R20). It has been suggested that R2 is sensitive
to many physiological perturbations, including tissue
water content, inflammation and changes in tissue
oxygenation. However, R2 is linearly dependent on
tissue oxygenation. Therefore, R2 is able to provide a
more specific and direct evaluation of muscle
oxygenation. Muscle BOLD MRI has been used to infer
small vessel function following arterial occlusion, the
infusion of vasoactive compounds and to study vascular
function in peripheral artery disease. BOLD R2* is a
summation of irreversible (R2) and reversible(R2)
relaxation rates (R2*=R2+R20). It has been suggested
that R2 is sensitive to many physiological
perturbations, including tissue water content,
inflammation and changes in tissue oxygenation. However,
R2 is linearly dependent on tissue oxygenation.
Therefore, R2 is able to provide a more specific and
direct evaluation of muscle oxygenation.
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