Abstract #1189
Topographic Modifications of T1-Gd in Early Osteoarthritic Tibial Cartilage by MRI at Microscopic Resolution
Ji hyun Lee 1 , Farid Badar 2 , and Yang Xia 3,4
1
Oakland Univ, Rochester, Michigan, United
States,
2
Oakland
Univ, Michigan, United States,
3
Physics,
Oakland University, Rochester, Michigan, United States,
4
Center
for Biomedical Research, Oakland University, Michigan,
United States
This study quantified the topographical and zonal
changes of T1 in healthy and osteoarthritic tibial
cartilage in canines. T1 of cartilage when soaked in
gadolinium showed an increasing trend from the surface
to deep cartilage. The zonal T1 values from the
meniscus-covered area were significantly higher than
those from the uncovered area for most sub-tissue zones
(except the deepest tissue and bulk). The average T1
decreased with OA advance and the cartilage thickness
increased at early osteoarthritic lesion. This study
could help to design more effective protocols to detect
the early lesions in the clinics.
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