Abstract #1152
Sensitive Detection of Zinc(II) in the Prostate with a Gadolinium-Based MRI Contrast Agent
Veronica Clavijo Jordan 1,2 , Christian Preihs 1 , Shiuhwei Chen 3 , Shanrong Zhang 1 , Wen-hong Li 3 , Neil Rofsky 2 , and Dean Sherry 1,4
1
Advanced Imaging Research Center, UT
Southwestern Medical Center, Dallas, Texas, United
States,
2
Department
of Radiology, UT Southwestern Medical Center, Dallas,
Texas, United States,
3
Departments
of Cell Biology and of Biochemistry, UT Southwestern
Medical Center, Dallas, Texas, United States,
4
Department
of Chemistry, UT Dallas, Texas, United States
Due to the lack of accuracy in current prostate cancer
testing methods, there is an increasing need for more
reliable tests to differentiate prostate cancer from
benign prostatic hyperplasia (BPH), prostatic
intraepithelial neoplasia, and/or inflammation. The
reported loss of zinc in prostate cancer offers a
potential mechanism to distinguish malignancy from the
other conditions. Here we introduce a gadolinium-based
sensor that can report the available zinc(II) present in
the prostate sensitively. We also report the role of
glucose in secreting zinc(II) in prostate secretory
cells.
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