Abstract #1148
Modelling tissue microstructure in bone metastases from prostate cancer using VERDICT MRI
Colleen Bailey 1 , Eleftheria Panagiotaki 1 , Nina Tunariu 2 , Matthew R Orton 3 , Veronica A Morgan 3 , Thorsten Feiweier 4 , David J Hawkes 1 , Martin O Leach 3 , David J Collins 3 , and Daniel C Alexander 1
1
Centre for Medical Image Computing,
University College London, London, United Kingdom,
2
Radiology,
Royal Marsden NHS Foundation Trust and Institute of
Cancer Research, Sutton, United Kingdom,
3
CR-UK
and EPSRC Cancer Imaging Centre, Institute of Cancer
Research and Royal Marsden NHS Foundation Trust, London,
United Kingdom,
4
Healthcare
Sector, Siemens AG, Erlangen, Germany
Bone metastases in men with advanced prostate cancer
were examined by diffusion MRI with varying diffusion
times and gradient strengths. Data were fitted to
3-compartment models of diffusion that included a
perfusion compartment, an extracellular compartment and
an intracellular spherically-restricted compartment.
Data showed variation for points with the same b-value
but different diffusion time and were better explained
by a model incorporating restriction than either
conventional ADC or 2- or 3-compartment models with free
diffusion. Model parameters indicated a low perfusion
fraction (<10%), intracellular volume fraction 0.22-0.56
and a cell radius between 4.7-9.9 m.
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