Abstract #1113
19F MRSI of capecitabine in the liver using broadband TxRx antennas and dual-frequency excitation pulses at 7T
Jetse van Gorp 1 , Peter Seevinck 1 , Anna Andreychenko 2 , Alexander Raaijmakers 2 , Peter Luijten 3 , Miriam Koopman 4 , Vincent Boer 3 , and Dennis Klomp 3
1
Image Sciences Institute, University Medical
Center Utrecht, Utrecht, Utrecht, Netherlands,
2
Department
of Radiotherapy, University Medical Center Utrecht,
Utrecht, Utrecht, Netherlands,
3
Department of
Radiology, University Medical Center Utrecht, Utrecht,
Utrecht, Netherlands,
4
Department
of Medical Oncology, University Medical Center Utrecht,
Utrecht, Utrecht, Netherlands
In this work, the feasibility to detect orally
administered chemotherapy (capecitabine) in the liver
was investigated at a clinical 7T MR system. The system
was equipped with a broadband radiative antenna to
acquire both 1H and 19F signal, and dual-frequency
excitation pulses were implemented to overcome
excitation issues. Pulse acquire and 3D spectroscopic
imaging 19F spectra were successfully acquired in two
patients at 1 and 10 hours after drug intake. The
results show that it is feasible to monitor chemotherapy
metabolism at 7T in the human body.
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