Abstract #1112
Investigating pH and other effects of a proton pump inhibitor (PPI) in cancer models with 31 P magnetic resonance
Gopal Varma 1 , Xiaoen Wang 1 , Han Xie 2 , Gerburg Wulf 3 , Pankaj Seth 2 , David C Alsop 1 , Aaron K Grant 1 , and Vikas P Sukhatme 2
1
Radiology, Division of MR Research, Beth
Israel Deaconess Medical Center, Harvard Medical School,
Boston, Massachusetts, United States,
2
Department
of Medicine, Beth Israel Deaconess Medical Center,
Harvard Medical School, Boston, Massachusetts, United
States,
3
Division
of Hematology and Oncology, Department of Medicine, Beth
Israel Deaconess Medical Center, Harvard Medical School,
Boston, Massachusetts, United States
Proton pump inhibitors (PPIs) hold potential for
treatment of cancer treatment by disrupting the
transport of excess hydrogen ions out of cancer cells
that maintains a normal intracellular pH and forms an
acidic extracellular environment. The effect of a PPI
combination on preclinical models of breast and
non-small cell lung cancer was studied using
slice-selective 31P spectroscopy through the tumor up to
40 minutes post drug injection. Intracellular pH
decreased significantly following treatment. In
addition, a more significant increase in Pi/γATP ratio
from pre- to post-injection periods was observed.
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