Abstract #1107
Evaluation of nanoparticle accumulation and treatment efficacy for a combined heavy-ion-beam irradiation and drug-delivery tumor therapy
Daisuke Kokuryo 1 , Eiji Yuba 2 , Kenji Kono 2 , Tsuneo Saga 1 , and Ichio Aoki 1
1
Molecular Imaging Center, National Institute
of Radiological Sciences, Chiba, Chiba, Japan,
2
Graduate
School of Engineering, Osaka Prefecture University,
Sakai, Osaka, Japan
A combination treatment using carbon-ion-beam
irradiation and multimodal thermo-sensitive
polymer-modified liposomes (MTPLs) containing contrast
agents and anti-cancer drug was developed. The
accumulation and treatment effects of the MTPLs were
evaluated in
in
vivo
experiments
on subcutaneously xenografted tumor model mice. MTPLs
accumulated in the tumor region regardless of the
influence of carbon-beam irradiation and the efficacy of
the combination treatment increased after
heat-triggering of drug release. It was concluded that
the proposed strategy provided an effective anti-cancer
treatment.
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