Abstract #1106
Importance of characterizing water content in quantifying metabolites in pancreatic cancer and normal pancreas
Marie-France Penet 1 , Balaji Krishnamachary 1 , Tariq Shah 1 , Yelena Mironchik 1 , Anirban Maitra 2 , and Zaver M Bhujwalla 1
1
JHU ICMIC Program, Division of Cancer
Imaging Research, The Russell H Morgan Department of
Radiology, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States,
2
MD
Anderson Cancer Center, The University of Texas, TX,
United States
There is a critical need for identifying and developing
new noninvasive biomarkers and therapeutic targets in
pancreatic cancer. We recently observed aberrant choline
metabolism in subcutaneous and orthotopically implanted
human pancreatic cancer xenografts using 1H MR
spectroscopic imaging. However, high-resolution proton
spectra of tumors and pancreatic tissue extracts
normalized to the water signal assuming similar water
content did not reflect the significantly increased
total choline observed in vivo. Our purpose here was to
determine the differences in water content between
pancreatic tumors and the pancreas to accurately
quantify differences in metabolism when using the water
signal for normalization.
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