Abstract #1090
Highly Accelerated DCE-MRI Pharmacokinetic map Estimation through frequency domain based Tofts model (HAET)
Nithin N Vajuvalli 1 , C K Dharmendra Kumar 1 , Manoj G Bhosale 1,2 , and Sairam Geethanath 1
1
Medical Imaging Research Centre, Dayananda
Sagar College of Engineering, Bangalore, Karnataka,
India,
2
Government
College of Engineering (COEP), Pune, Maharastra, India
DCE-MRI is used to assess tumor perfusion, microvascular
vessel wall permeability and extravascularextracellular
volume fraction. Tofts Model (TM) in Time Domain (TD) is
computationally intensive for 3D data to obtain
Pharmacokinetic (PK) map using curve fitting. The
current work involves acceleration of curve fitting
process for the computation of PK map using Frequency
Domain (FD) based TM. Current work was demonstrated on
seven breast DCE datasets. Result show reduced
computational time for estimating PK map and reduced
NRMSE values in FD as compared to TD tofts model with
respect to randomly generated ground truth and in vivo
data.
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