Abstract #1063
Voxelwise DTI group analysis in professional fighter population
Wanyong Shin 1 , Blessy Mathew 1 , Banks Sarah 2 , Mark J Lowe 1 , Michael Phillips 1 , Modic T Michael 3 , and Charles Bernick 2
1
Imaging Institute, Cleveland Clinic
Foundatoin, Cleveland, Ohio, United States,
2
Lou
Ruvo Center for Brain Health, Cleveland Clinic
Foundation, Las Vegas, Nervada, United States,
3
Neurological
Institute, Cleveland Clinic Founcatoin, Cleveland, Ohio,
United States
The Professional Fighters Brain Health Study (PFBHS) is
a longitudinal cohort study that is following active
professional fighters annually over 4 years. From the
initial data including 74 boxers and 84 mixed martial
art (MMA) fighters, ROI based DTI results have been
published that show that the number of times a fighter
has been knocked out (NKO) predicts DTI changes mainly
in posterior corpus callosum. [1]. In this study, we
included all the baseline visits of the male fighters in
PFBHS (N=305) and performed a voxelwise DTI group
analysis using non-linear registration method to
investigate if fight exposure history predicts DTI
measures of white matter integrity in whole brain. We
found that NKO predicts DTI changes mainly in corpus
callosum and splenium of corpus callosum after
controlling age and education effects.
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