Abstract #1062
Magnetization transfer ratio detects myelin loss in thalamocortical pathways more consistently than DTI after a traumatic brain injury in rat
Lauri Juhani Lehto 1 , Alejandra Sierra 1 , Asla Pitknen 1,2 , and Olli Grhn 1
1
Neurobiology, University of Eastern Finland,
Kuopio, Eastern Finland, Finland,
2
Neurology,
Kuopio University Hospital, Kuopio, Eastern Finland,
Finland
Magnetization transfer (MT) weighted imaging and
diffusion tensor imaging (DTI) were performed in rats
with experimental traumatic brain injury (TBI) at six
months post-TBI. Results were validated by analyzing
histological sections. MT ratio (MTR) followed
consistently the severity of myelin loss whereas
fractional anisotropy gave seemingly mixed results. In
line with histology, MTR revealed cortical and white
matter damage ipsilateral to injury, particularly in the
myelinated thalamocortical pathway. MTR appears be a
more sensitive tool than DTI for assessing changes in
the myelin integrity after TBI.
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