Abstract #0925
B 0 -orientation dependent susceptibility-induced white matter contrast in the human brainstem
Manisha Aggarwal 1 , Xu Li 2 , Susumu Mori 1,2 , and Peter C. M. van Zijl 1,2
1
Department of Radiology, Johns Hopkins
University School of Medicine, Baltimore, MD, United
States,
2
F.M.
Kirby Research Center, Kennedy Krieger Institute,
Baltimore, MD, United States
In this study, we investigate susceptibility-induced B
0
-orientation
dependence of the apparent relaxation rate (R
2
*)
and signal frequency measurements in the ex vivo fixed
human brainstem. Gradient echo (GRE) data acquired at
11.7T showed distinct modulation of R
2
* and
frequency contrasts between the corticospinal and
transverse pontine fibers in the brainstem, which
closely approximated sin
4
θ and sin
2
θ
dependencies on orientation relative to the static B
0
field.
We further investigate the estimation of fiber
orientation maps based on the modulated R
2
*
curves, and compare the results with primary eigenvector
maps derived using diffusion MRI.
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