Abstract #0804
Profiling muscle substrate utilization in insulin-resistant subjects using 13 C-MRS at 7 Tesla
Douglas E Befroy 1,2 , Kitt Falk Petersen 2 , Douglas L Rothman 1,3 , and Gerald I Shulman 2,4
1
Diagnostic Radiology, Yale University School
of Medicine, New Haven, CT, United States,
2
Internal
Medicine, Yale University School of Medicine, New Haven,
CT, United States,
3
Biomedical
Engineering, Yale University School of Medicine, New
Haven, CT, United States,
4
Howard
Hughes Medical Institute, New Haven, CT, United States
Insulin resistance is accompanied by derangements in a
variety of parameters of muscle metabolism including
insulin-stimulated glucose disposal and glycogen
synthesis as well as basal rates of mitochondrial
metabolism. To date, technological and methodological
limitations have required that each of these parameters
be assessed as distinct experiments, which can
complicate comparison between studies. We have developed
an innovative dual
13
C-tracer
method to assess muscle glucose utilization and
oxidative metabolism during a single
13
C-MRS
study at 7 Tesla. The ability to comprehensively examine
muscle substrate utilization
in
vivo
will
advance our understanding of skeletal muscle metabolism.
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