Abstract #0739
1 H MRS Demonstrates Elevations of Prefrontal Cortex GABA in Major Depressive Disorder after Treatment with Repetitive Transcranial Magnetic Stimulation
Marc J Dubin 1 , Xiangling Mao 2 , Samprit Banerjee 3 , Rebecca Gordon 4 , Zachary Goodman 5 , Kyle AB Lapidus 6 , Guoxin Kang 2 , Conor Liston 1 , and Dikoma C Shungu 2
1
Psychiatry & Brain and Mind Research
Institute, Weill Cornell Medical College, New York, NY,
United States,
2
Radiology,
Weill Cornell Medical College, New York, NY, United
States,
3
Healthcare
Policy and Research, Weill Cornell Medical College, New
York, NY, United States,
4
Psychiatry,
Weill Cornell Medical College, New York, NY, United
States,
5
Johns
Hopkins University, Baltimore, MD, United States,
6
Psychiatry,
Icahn School of Medicine at Mount Sinai, New York, NY,
United States
Although repetitive transcranial magnetic stimulation
(rTMS) is an effective treatment for major depressive
disorder (MDD), its antidepressant mechanisms are
unclear. This study investigated the potential
involvement of GABA and glutamate in the antidepressant
mechanism of rTMS. Patients with MDD underwent a 5-week
treatment of rTMS, with
1
H
MRS measurements of prefrontal GABA and Glx pre- and
post-treatment. After rTMS treatment, prefrontal GABA
increased 12.3% in all depressed subjects and 18.3% in
subjects with partial or full responses. Glx was
unchanged. These results seem to implicate GABAergic and
glutamatergic systems in the antidepressant mechanism of
action of rTMS.
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