Abstract #0736
The Impact of Ebselen Administration on Brain myo-Inositol Concentration
Uzay E Emir 1 , Nisha Singh 2,3 , Ann Sharpley 3 , Charles Masaki 3 , Sridhar Vasudevan 2 , Peter Jezzard 1 , Phil Cowen 3 , and Grant Churchill 2
1
University of Oxford, FMRIB Centre, Oxford,
Oxfordshire, United Kingdom,
2
University
of Oxford, Department of Pharmacology, Oxford,
Oxfordshire, United Kingdom,
3
University
of Oxford, Department of Psychiatry, Oxford,
Oxfordshire, United Kingdom
Bipolar disorder (BPD) is a relatively common
psychiatric disorder for which lithium is the gold
standard of treatment but it has a number of
side-effects which require careful monitoring of plasma
levels of the drug. A drug, ebselen, that mimics the
effect of lithium but without its side-effects has been
recently reported. In this study, we assessed if ebselen
reduces brain inositol levels, compared to placebo using
magnetic resonance spectroscopy.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
