Abstract #0735
Lithium brain absorption in the elderly versus younger patients with bipolar disease.
Maria Otaduy 1 , Ivan Aprahaiam 2 , Rodolfo Ladeira 2 , Rodrigo Machado-Vieira 3,4 , Claudia Leite 5 , Wagner Gattaz 6 , and Orestes Forlenza 2
1
Laboratory of Magnetic Resonance in
Neuroradiology, LIM 44, Institute and Department of
Radiology, University of So Paulo, So Paulo, So
Paulo, Brazil,
2
Laboratory
of Neuroscience, LIM 27, Institute and Department of
Psychiatry, University of So Paulo, So Paulo, So
Paulo, Brazil,
3
Laboratory
of Neuroscience, LIM 27, Institute and Department of
Psychiatry, University of So Paulo, So Paulo, Brazil,
4
Department
of Health and Human Services, National Institute of
Mental Health, National Institutes of Health, Bethesda,
MD, United States,
5
Laboratory
of Magnetic Resonance in Neuroradiology, LIM 44,
Institute and Department of Radiology, University of So
Paulo, Sao Paulo, Brazil,
6
Laboratory
of Neuroscience, LIM 27, Institute and Department of
Psychiatry, University of So Paulo, So Paulo, Sao
Paulo, Brazil
In this study we used 7Li-MRS to quantify brain lithium
concentration in patients with bipolar disease under
lithium treatment. The purpose of this study was to
evaluate if lithium brain absorption is different in
young (20-40yrs) from elderly (60-80yrs) patients. For
that we evaluated the mean brain to plasma lithium ratio
for both groups and found it to be the same. Noteworthy,
within the younger group we found a negative correlation
between brain to plasma lithium ratio and age that was
not observed for the elderly group.
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