Abstract #0723
Contralateral cortico-ponto-cerebellar pathways with prominent involvement of associative areas in humans in vivo
Andrea De Rinaldis 1,2 , Fulvia Palesi 2,3 , Gloria Castellazzi 1,2 , Fernando Calamante 4,5 , Nils Muhlert 6,7 , J Donald Tournier 4,5 , Giovanni Magenes 1 , Egidio D'Angelo 2,8 , and Claudia AM Wheeler-Kingshott 6
1
Department of Electrical, Computer and
Biomedical Engineering, University of Pavia, Pavia, PV,
Italy,
2
Brain
Connectivity Center, C. Mondino National Neurological
Institute, Pavia, PV, Italy,
3
Department
of Physics, University of Pavia, Pavia, PV, Italy,
4
The
Florey Institute of Neuroscience and Mental Health,
Melbourne Brain Centre, Heidelberg, Victoria, Australia,
5
Department
of Medicine, Austin Health and Northern Health,
University of Melbourne, Heidelberg, Victoria,
Australia,
6
NMR
Research Unit, Department of Neuroinflammation, Queen
Square MS Centre, UCL Institute of Neurology, London,
England, United Kingdom,
7
Department
of Psychology, Cardiff University, Cardiff, Wales,
United Kingdom,
8
Department
of Brain and Behavioral Sciences, University of Pavia,
Pavia, PV, Italy
Cerebellar involvement in cognition is becoming
increasingly evident; this is thought to occur through
the cerebello-cortical loop, composed of two main
pathways: an efferent cerebello-thalamo-cortical pathway
and an afferent cortico-ponto-cerebellar pathway. The
former has already been reconstructed in vivo using
probabilistic tractography. We applied the same method
to reconstruct the latter pathway and to describe it
both anatomically and quantitatively. The main finding
is that most of the cortico-ponto-cerebellar streamlines
connect cerebral associative areas with their cerebellar
cognitive counterpart. This result improves our
understanding of cerebello-cortical connections and
provide a plausible pathway through which the cerebellum
can influence cognition.
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