Abstract #0670
Quantitative Perfusion Measurements in Renal Masses with Arterial Spin Labeling and Dynamic Contrast Enhanced MRI at 3T Correlate with Microvessel Density at Histopathology
Yue Zhang 1 , Payal Kapur 2,3 , Qing Yuan 1 , Ananth Madhuranthakam 1,4 , Ingrid Carvo 5 , Sabina Signoretti 5 , Ivan Dimitrov 6 , Yin Xi 1 , Katherine Wicks 1 , Jeffrey Cadeddu 1,3 , Vitaly Margulis 3 , James Brugarolas 7,8 , and Ivan Pedrosa 1,4
1
Radiology, University of Texas Southwestern
Medical Center, Dallas, Texas, United States,
2
Pathology,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States,
3
Urology,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States,
4
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, United
States,
5
Pathology,
Brigham and Womens Hospital, Boston, Massachusetts,
United States,
6
Philips
Medical Systems, Cleveland, Ohio, United States,
7
Internal
Medicine, University of Texas Southwestern Medical
Center, Dallas, Texas, United States,
8
Developmental
Biology, University of Texas Southwestern Medical
Center, Dallas, Texas, United States
Our aim was to investigate the correlation between
in
vivo
perfusion
measurement of renal masses by arterial spin labeling
(ASL) and dynamic contrast-enhanced (DCE) MRI at 3T and
validate these results against microvessel density (MVD)
at histopathology. Quantitative ASL perfusion (
P
ASL
)
and DCE parameters were obtained from the whole tumor,
and from areas with high- and low- perfusion within the
tumor. ASL measured blood flow in renal masses
correlates with DCE-derived parameters.
P
ASL
,
K
trans
,
and
Kep
correlate
with MVD. ASL and DCE MRI at 3T provide a tool for
assessing angiogenesis in renal cancer.
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