Abstract #0669
Dynamic Contrast Enhanced MRI Estimate of Tumor Interstitial Fluid Pressure in Solid Brain Tumors
Madhava P Aryal 1 , Tavarekere N Nagaraja 2 , Rasha Elmghribi 1,3 , Kelly A Keenan 2 , Swayamprava Panda 1 , Glauber Cabral 1 , Stephen L Brown 4 , and James R Ewing 1,3
1
Dept. of Neurology, Henry Ford Hospital,
Detroit, MI, United States,
2
Dept.
of Anesthesiology, Henry Ford Hospital, Detroit, MI,
United States,
3
Dept.
of Physics, Oakland University, Rochester, MI, United
States,
4
Dept.
of Radiation Oncology, Henry Ford Hospital, Detroit, MI,
United States
In many solid tumors an elevated tumor interstitial
fluid pressure (TIFP) is a central and potentially
critical element for assessing therapeutic response. The
present study examined the possibility of evaluating
TIFP non-invasively using dynamic contrast enhanced MRI
(DCE-MRI) data in a rat model of cerebral glioma. A
significant correlation between DCE-MRI derived TIFPs
with those of WIN estimates (n=9, R=0.77, p≤0.02) was
established. These data strongly demonstrate the
possibility of employing DCE-MRI for non-invasive
estimates of TIFP in solid tumors, and also provides a
means for estimating fluid conductivity in tumor
surround.
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