Abstract #0539
Feasibility and Repeatability of Human Brown Adipose Tissue Volume and Perfusion Activity Using MRI
Weiying Dai 1 , Lauren S. Weiner 2 , David C. Alsop 1 , and Aaron M. Cypess 2
1
Radiology, Beth Israel Deaconess Medical
Center & Harvard Medical School, Boston, MA, United
States,
2
2Section
of Integrative Physiology and Metabolism, Joslin
Diabetes Center, Boston, MA, United States
Brown adipose tissue (BAT) can improve insulin
sensitivity and hence may prove to be an important
anti-diabetic tissue. The volume and activity of BAT
have previously been measured using 18F-FDG PET/CT.
Here, we demonstrate the feasibility and repeatability
of using Dixon water/fat imaging and ASL imaging to
assess BAT volume and perfusion responses to mild cold
stimulation in the cervical area of adult humans. The
Dixon method can provide a quantitative measurement of
the BAT volume. ASL shows great promise for measuring
perfusion activity within BAT and can be successful if
the vessel signals near the BAT are well suppressed.
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