Abstract #0472
Improving the interpretation of diffusional kurtosis by resolving effects of isotropic and anisotropic microstructures
Filip Szczepankiewicz 1 , Danielle van Westen 2,3 , Jimmy Ltt 2 , Elisabet Englund 3 , Carl-Fredrik Westin 4 , Freddy Sthlberg 1,3 , Pia C. Sundgren 2,3 , and Markus Nilsson 5
1
Dept. of Medical Radiation Physics, Lund
University, Lund, Sweden,
2
Imaging
and Function, Skne University Healthcare, Lund, Sweden,
3
Dept.
of Clinical Sciences, Lund University, Skne University
Healthcare, Lund, Sweden,
4
Dept.
of Radiology, Brigham and Womens Hospital, Harvard
Medical School, Boston, MA, United States,
5
Lund
University Bioimaging Center, Lund University, Lund,
Sweden
In this work we separate diffusional kurtosis into
components rendered by isotropic and anisotropic
microstructural features, by combining conventional and
single-shot isotropic diffusion encoding. We show that
glioma and meningioma tumors exhibit two radically
different origins of kurtosity in vivo. This indicates
that the gliomas and meningiomas contain isotropic
domains with varying diffusivity, and randomly oriented
anisotropic domains, respectively. Finally, we conclude
that disentangling the origins of diffusional kurtosis
improves the sensitivity and specificity of kurtosis
parameters as well as the ability to interpret such
parameters.
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