Abstract #0471
Microstructural Information from Single-Pulsed-Field-Gradient and Angular Double-Pulsed-Field-Gradient NMR: From Model Systems to Nerves
Darya Morozov 1 , Leah Bar 1 , Nir Sochen 1 , and Yoram Cohen 1
1
The Raymond and Beverly Sackler Faculty of
Exact Science, Tel-Aviv University, Tel-Aviv Yaffo,
Tel-Aviv Yaffo, Israel
Water diffusion in neuronal tissues, at high diffusion
weighting and sufficient long diffusion times, becomes
non-Gaussian. Under such conditions conventional DWI and
DTI data does not accurately describe water diffusion in
the CNS. However when complex biological specimens are
studied it is of value to test the new methodology on
real, complex samples where the ground truth is known a
priori. In the present work we modeled the signal from
single (s-) and angular double-pulsed-field-gradient
(d-PFG) diffusion NMR experiments performed on a series
of well-defined phantoms of increasing complexity and on
isolated pig optic nerves.
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