Abstract #0463
Susceptibility tensor imaging reveals reduced anisotropy in renal nephropathy
Luke Xie 1 , Russell Dibb 1,2 , Susan B. Gurley 3 , Chunlei Liu 1,4 , and G. Allan Johnson 1,2
1
Center for In Vivo Microscopy, Duke
University Medical Center, Durham, North Carolina,
United States,
2
Biomedical
Engineering, Duke University, Durham, North Carolina,
United States,
3
Division
of Nephrology, Department of Medicine, Duke University
and Durham VA Medical Centers, Durham, North Carolina,
United States,
4
Brain
Imaging Analysis Center, Duke University Medical Center,
Durham, North Carolina, United States
In normal kidneys, DTI and susceptibility tensor imaging
(STI) can detect and track tubules in the inner medulla.
We investigated whether STI can be more sensitive than
DTI in models of renal nephropathy (angiotensin receptor
knockout and diabetic nephropathy). We found that DTI
fractional anisotropy and tractography exhibited some
changes in the inner medulla of diseased kidneys. STI,
on the other hand, had significantly reduced anisotropy
and virtually did not track any tubules in the inner
medulla. STI therefore was more sensitive to injury in
renal tubules.
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