Abstract #0462
Measuring Single Nephron Filtration with Molecular MRI
Edwin J Baldelomar 1 , Jennifer Charlton 2 , and Kevin M. Bennett 3
1
Physics, University of Hawaii at Manoa,
Honolulu, Hawaii, United States,
2
University
of Virginia, Virginia, United States,
3
Biology,
University of Hawaii at Manoa, Hawaii, United States
Here we investigated the use of two MRI contrast agents,
cationic ferritin (CF) and gd-DTPA, to measure local
macromolecular filtration and glomerular filtration
rates in 3D MRI at voxel resolution in isolated,
perfused rat kidneys under physiological conditions. CF
is a glomerulus-specific, superparamagentic targeted
nanoparticle (*ref), and gd-DTPA is eliminated through
the tubule. CF uptake rate was thus measured dynamically
as a marker for macromolecular filtration, and Gd-DTPA
passage was used as a marker for local (voxel)
glomerular filtration.
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