Abstract #0436
Relationship Between Structure and Function of the Auditory System is Altered in 16p11.2 Deletion and Duplication
Jeffrey I Berman 1,2 , Julian Jenkins 1 , Darina Chudnovskaya 1 , Srikantan Nagarajan 3 , Pratik Mukherjee 3 , Randy Buckner 4 , John E Spiro 5 , Wendy K Chung 6 , Elliott H Sherr 7 , and Timothy PL Roberts 1,2
1
Radiology, Children's Hospital of
Philadelphia, Philadelphia, Pennsylvania, United States,
2
Radiology,
University of Pennsylvania, Philadelphia, Pennsylvania,
United States,
3
Radiology,
University of California San Francisco, California,
United States,
4
Psychology,
Harvard University, Boston, Massachusetts, United
States,
5
Simons
Foundation, New York, United States,
6
Pediatrics
and Medicine, Columbia University Medical Center, New
York, United States,
7
Neurology,
University of California San Francisco, California,
United States
Deletion and duplication of chromosome 16p11.2has been
associated with developmental disorders such as autism
spectrum disorders (ASD). This multimodal study
hypothesizes that the relationship between auditory
radiation microstructure and the timing of the auditory
evoked response (M100) is altered in children with
16p11.2 deletions and duplications. Diffusion MR and MEG
were performed on 39 controls, 30 deletion carriers, and
9 duplication carriers. In the controls, low M100 was
significantly correlated with low diffusivity. In the
deletion and duplication populations, no significant
correlation between DTI metrics and M100 was observed.
This multimodal study indicates varying gene doses may
similarly have an abnormal structure-function
relationship.
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