Abstract #0435
Characterization of Hemodynamic Alterations in Autism using Resting State fMRI
Wenjing Yan 1 and Gopikrishna Deshpande 1,2
1
AU MRI Research Center,Department of
Electrical and Computer Engineering, Auburn University,
Auburn, Alabama, United States,
2
Department
of Psychology, Auburn University, Alabama, United States
Functional MRI studies of Autism attribute all changes
in the fMRI signal to underlying neural activity,
assuming an unaltered hemodynamic response function
(HRF) in Autism. However, recent evidence from
molecular/cellular approaches indicates that some
neurovascular alterations may exist in the autistic
brain. Therefore, we hypothesized that voxel-wise HRF
derived from blind deconvolution of resting state fMRI
will be altered in the autistic brain. We found
significant group differences in HRF parameters in the
frontal, temporal and motor areas, indicating that
alterations based on the fMRI signal in Autism cannot be
entirely attributed to underlying neural activity.
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