Abstract #0416
Radical-free mixture of co-polarized 13C-metabolites for probing separate biochemical pathways simultaneously in vivo by hyperpolarized 13C MR
Jessica AM Bastiaansen 1,2 , Hikari AI Yoshihara 3,4 , Andrea Capozzi 3 , Juerg Schwitter 4 , Matthew E Merritt 5 , and Arnaud Comment 3
1
Department of Radiology, University Hospital
(CHUV) and University of Lausanne (UNIL), Lausanne,
Switzerland,
2
Center
for Biomedical Imaging (CIBM), Lausanne, Switzerland,
3
Institute
of Physics of Biological Systems, EPFL, Lausanne,
Switzerland,
4
Division
of Cardiology and Cardiac MR Center, University Hospital
Lausanne (CHUV), Lausanne, Switzerland,
5
Advanced
Imaging Research Center,Department of
Radiology,Molecular Biophysics,Biomedical Engineering,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States
The combination of hyperpolarized 13C technology and
co-administration of separate imaging agents enables
simultaneous monitoring of separate metabolic pathways
in vivo in a single experiment. However, for clinical
applications, it is currently necessary to use 13C
preparations containing persistent radicals which
require a time consuming filtration process before the
injection, resulting in polarization losses. Here we
present a radical-free, additive-free method, to
co-hyperpolarize mixtures of 13C-labeled metabolites and
respective in vivo detection in the heart. This study
illustrates a method for measuring substrate competition
that could be generalized to humans.
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